Life Extension using Melatonin
extracts from The Gilgamesh Project by Andrew Sokar

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Melatonin: Health Notes Article discusses the purpose of this Essential Hormoneicon


...The hormone, melatonin, is secreted by the pineal gland; it plays a role not only in the regulation of the sleep-wake cycle, but also in prolonging life span and in some cases, halting and even reversing some of the symptoms of ageing in laboratory animals and humans. The hormone also has anti-cancer activity. Such research, mostly performed in Europe, is amply cited in Dr Walter Pierpaoli's 1995 bestseller The Melatonin Miracleicon, and need not be dealt with in depth here. Since melatonin is already a commonly sold health supplement, it cannot be patented by pharmaceutical companies and consequently has marshalled little interest from the medical establishment, at least on this side of the Atlantic.

Melatonin has been used to successfully treat the following maladies:

Angelman©s syndrome (sleep disturbances only)

Cluster headaches

Colon cancer

Depression

Insomnia

Jet lag

Schizophrenia (for sleep disturbances only)

Tardive dyskinesia

Tinnitus (insomnia-associated)

Melatonin is a natural substance made by the pineal gland located in the brain. Adequate melatonin levels help to establish healthy sleep patterns. It is released primarily during the night. Melatonin levels decrease as we get older.


The benefit of sublinguals: Some nutrients may break down during liver metabolism. The sublingual form is aborbed directy into the bloodstream, via the blood vessels under the tongue and in the cheeks, bypassing the liver and allowing for quick entry into the system. Suitable for vegetarians. Orange flavor. Other Sublinguals: Natrol Melatonin 5mg, Strawberry Flavored, 90 Fast Dissolve Tablets

Melatonin is an important, but relatively small piece of the overall puzzle and my work has taken this line of research beyond Dr Pierpaoli's discoveries into wholly uncharted territory.

Synthesising this diverse basic research with the results of my own work in cell culture and in vivo, I have formulated the following general conclusions:

1. Melatonin's anti-aging and anti-cancer effects are at least in part due to the fact that this hormone, after it leaves the pineal gland (where it is made), travels to the thymus gland located behind the breastbone and possibly other endocrine glands where it functions as a "releasing hormone" and modulates the synthesis of at least two other chemically distinct hormones unacknowledged by medical science which I will label only as hormone "X" and hormone "Y" for our purposes here. I have identified the chemical structures of these substances.

2. It is both the relative and absolute ambient levels of hormones X and Y in the body that modulate cellular growth, aging and differentiation phenomena. This effect is in turn probably modulated by melatonin and at least one trace metal or its organometallic complexes. Preliminary indications are that these interactions are complex and remain largely unknown due to the limitations in funds and facilities under which my previous work has been carried out. The production of these substances is probably governed by complex feedback loops that involve the sex hormones, thyroid hormones, etc. Elucidating these relationships must remain one goal for future research.

3. The thymus gland begins the process of involution after the chronological age of 20-30 years in humans. The pineal also calcifies and deteriorates. That is why CT and NMR scans of the heads of older individuals reveal a white pea-sized object in the basal area of the brain which I have seen many people mistake for alien implants. I submit that the deterioration of these glands precipitates a deflection in the concentrations of hormone X, hormone Y, or both. The magnitude and direction (up or down) of these deflections is unknown, but is probably downward.

4. It is this perturbation in the levels of hormones X and/or Y that triggers cell senescence and eventual death, causing tissues to stop turning over and precipitating the physical declines associated with ageing. Since one of these hormones is involved in maintaining cells in a differentiated state, this could provide the long-awaited answer as to why cancer prevalence in general increases as we age, and also why sexual differentiation and other tissue differentiation declines in the same interval.

Melatonin - Monograph.
Altern Med Rev. 2005 Dec;10(4):326-336. Related Articles,© Links©

Melatonin, the primary hormone of the pineal gland, acts as a© powerful "chronobiotic," maintaining normal circadian rhythms. In patients© with sleep disorders and altered circadian rhythms, such as occur in jet lag,©night shift work, and various neuropsychiatric disorders, oral administration© of melatonin can provide the necessary resynchronization of those cycles, at©dosages ranging from 0.3 to 8 mg. Synthesis of melatonin from the amino acid© tryptophan is decreased by exposure to magnetic fields and by the aging© process.

Melatonin is a potent scavenger of free radicals and exerts direct© inhibition of cancer growth. Various cancer types have been shown to be© responsive to oral melatonin (10-50 mg daily), including breast cancer,© non-small-cell lung cancer, metastatic renal cell carcinoma, hepatocellular© carcinoma, and brain metastases from solid tumors.

Melatonin has also been© reported to lower LDL- and total cholesterol levels. Abnormally low melatonin levels have been theorized to be a factor in multiple sclerosis, coronary© heart disease, epilepsy, and postmenopausal osteoporosis. These reports, while© preliminary, serve to further illustrate the wide range of potential effects© exerted by melatonin.

PMID: 16366741 [PubMed - as supplied by© publisher]

5. Seemingly intractable problems can only be solved by reinterpreting the problems in novel ways. Cancer cells can be thought of as normal cells which have reverted to a de-differentiated state (i.e. they resemble rapidly dividing, undifferentiated embryonic cells rather than the mature, slowly dividing, properly behaving normal cells of the tissues from which they derive). It is also known to researchers that cancer cells are effectively immortal; if given a proper environment, they can live and reproduce indefinitely, just as can bacteria and certain types of plant and fungal cells. This finding alone indicates that ageing and death are not the inevitable fates that they are made out to be, but are instead the results of a program which can be altered. Although little has been made of this by conventional researchers, it strongly suggests that cancer is not a disease state, but a developmental problem, just as is ageing. Cancer cells are not behaving badly, they are just behaving in a manner inappropriate for their age. It is, in other words, a problem with the biological clock. Since melatonin is one of the substances that modulates the biological clock, this would explain melatonin's anti-cancer effects and also suggested to me that hormones X and Y might have similar effects.

6. Since the chemical structures of both hormones X and Y are attainable by traditional means of organic synthesis, their manufacture is relatively straightforward. As is also the case with many other currently acknowledged hormones such as the estrogens and progestins, it is possible to synthesize relatively low molecular weight analogues of hormones X and Y which retain the parent molecule's biological activity. I have prepared several analogues of this type. These compounds show the same cell growth altering abilities of the parent molecules although the resources available to me did not facilitate the kind of evaluation necessary to reach detailed conclusions of the precise actions of these compounds.

7. I have developed other compounds whose chemical structure is quite different from that of either hormones X or Y that seem to have similar effects on cancer cells.

8. The exact mechanism of action of these compounds must at this point remain an object of speculation, since I did not possess the funds or the facilities to properly investigate this issue. Based on the chemical structure of the compounds, however, it is reasonable to assume that, on a cellular level, they act in a manner similar to that of steroid hormones and retinoids (such as vitamin A).

This means that they probably penetrate the cell membrane and are then translocated to the nucleus where they either promote or inhibit the expression of genes which regulate the cell growth cycle. This is a much more sophisticated approach and stands in total contradistinction to the mode of action of virtually all existing anti-cancer drugs which are really little more than cellular poisons designed to kill off all rapidly dividing cells. Such a shotgun approach is responsible for the sometimes horrendous side effects associated with conventional chemotherapy...

This leads me to question whether ancient legends of fantastic life span for humans may not have a basis in reality. For example, thousands of years prior to the biblical era, a Sumerian legend relates the tale of a hero-type figure by the name of Gilgamesh who travelled far and wide in his quest for eternal life. He finally found a plant growing under water that was able to bestow the immortality that Gilgamesh sought. As the tale goes, however, instead of consuming the plant, he fell asleep. During his slumber, a snake ate the plant - hence the mythological explanation for snakes constantly shedding and renewing their skin. The moral lesson of the story is, I suppose, "you snooze, you lose." Due to Gilgamesh's carelessness, humankind was denied the secret of eternal life. Alas, mythological descriptions of the "plant," if that is what it was, are not sufficient to make a positive identification...


Age Gracefully and Beautifully

Aging is a natural process that everyone is subjected to. As a matter of fact, the aging process started kicking in the moment we were born. However, its unsightly effects are only felt when we start hitting middle age. Despite this, knowing what triggers the unwanted effects of aging and being aware of the right products can actually help you easily slow down or give the illusion that you have halted the aging process before its effects actually get on your nerves.

Many people are getting more and more afraid of facing the signs of aging. There is definitely no one in the world who would love seeing visible lines on their face or damaged skin complexions. Unfortunately, age sneaks up like a thief in the night. You might not like it nor appear to be combating it lightly but inevitably, you grow a year older after every three hundred sixty-five days.

As years add up to your age, they come with changes that take the youth in you. The function of the cells and organisms in your body shift, creating visible changes that sometimes come rapidly. The aging process may be different with each individual because there are many factors that contribute to it, but the bottom line is, everyone will surely get to it at one point of their lives or another.

Some of the bodily changes that you will experience include a significant difference in your weight and height. Weight increase is one of the major concerns that aging people wish to find a solution to. Reduced physical activity due to the weakness of the bones and muscles will definitely take its toll on your weight. Your height, on the other hand, naturally decreases as you get older. This is a result of a handful of factors like changes in posture and in the growth process of your spinal bones. Aside from these, your skin is also a fool proof sign that you are getting older. It becomes rough, loose, and dry. Women get more concerned about the skin changes than men because they tend to experience them faster. With the many hormonal changes women go through starting at the onset of puberty, pregnancy and menopause included, their skin rapidly becomes more vulnerable to age.

Your mental abilities may also become limiting as you grow older. Learning would be a lot more of hard work than, say, when you were on your twenties. Memory loss is also one of the more popular effects of aging. Older people are oftentimes forgetful because their brain process information slower than usual. Your mental fitness would also contribute to the many emotional combats that you will face. Anxiety and depression is very common among the older population because of the physical and mental limitations that they come across with.

Sexual performance is also greatly affected by aging. You may either lose the appetite or the ability to do it altogether.

Some say maintaining a constant supply of the magical Human Growth Hormones (HGH) is like enjoying a youthful life forever. HGH production peaks in adolescence and slowly decreases after you reach your twenties. The decrease is more significant as you grow older, which explains the overall difference that you experience if you are beyond your fifties. Low levels of HGH in your body system is the main reason behind the visibility of the signs of aging.

Among the many things that can be benefited from the aid of proper HGH levels are healthy skin, a more functional immune system, decreased body fat, increased muscle mass, increased bone density, low cholesterol, and high energy levels among others. The older population may submit themselves to an HGH Replacement Therapy to continuously enjoy the limitless possibilities of being young and healthy.

There are of course, things that you can do to enjoy the youthfulness of being young without having to go through pricey medications and therapies.

One is to maintain a healthy lifestyle, meaning, continuously participating in physical activities. Regular exercise is a good solution that will slow the aging process down without having to shell out bucks. A good exercise program that you follow regularly is the best answer to combat weight gain, muscle loss, bone density decline, or even any form of heart and cholesterol-related diseases for that matter.

Eating healthy is another trigger that could make you look and feel young longer. The right choices of foods and taking in the right amounts of them would create a great impact on your body's vitality. Do away with less fat, less salt, less sugar, and more greens, so your body could enjoy the most benefits from eating rather than suffering from the ugly consequences of not eating right.

Avoiding harmful vices like smoking and alcohol drinking can do loads to you more than you can imagine. Smoking is detrimental to the whole body. It triggers premature death but will not let you go looking young as well. The major components of cigarettes have harmful effects that are especially reflected on your complexion. Dry and rough skin can be caused by the poor circulation and low oxygen levels in your blood, which are generated through puffing airs of smokes. Alcohol, on the other hand, depletes your body of the vitamins and minerals it needed to be functional. It also causes dehydration. Keeping a stress-free and happy life most of the time would surely make you feel better about a lot of things and in the process, would make you age gracefully. Stress affects your body and your well-being greatly so make sure that you manage all the aspects of your life well including your career and your personal and social relationships with people.

Admittedly, the fast-paced era held back people to keep a healthy, balanced, and stress-free life only realizing later on that they should have done so. But by that time, you may well be reaching old age and would find it difficult to repair the damages that your old habits created. The good news is, there is a tried and tested way to help counteract the symptoms of aging in a no sweat fashion. GenF20 helps supply your body's needed HGH to maintain its youthful glow. It tackles all the ugly nightmares that most people worry about getting older. Amid all its benefits, GenF20 is also safe, so you will not have to worry about side effects.

Statements contained herein have not been evaluated by the fascist dictatorship, Food and Drug Administration, a greedy, Nazi type organization which gives preference to multinational pharmaceutical companies because of payola and other perks while attacking natural food suppliers. These products are not intended to diagnose, treat and cure or prevent disease. Always consult with your professional health care provider before changing any medication.

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