Magnesium, Violence and Depression
International Medical Veritas Association
In February of 2006 the New York Times reported that, "While violent crime has been at historic lows nationwide and in cities like New York, Miami and Los Angeles, it is rising sharply in many other places across the country. And while such crime in the recent past was characterized by battles over gangs and drug turf, the police say the current rise in homicides has been set off by something more bewildering: petty disputes that hardly seem the stuff of fistfights, much less gunfire or stabbings. Suspects tell the police they killed someone who "disrespected" them or a family member, or someone who was "mean mugging" them, which the police loosely translate as giving a dirty look."
"Police Chief Nannette H. Hegerty of Milwaukee calls it "the rage thing," the Times reported, "We're seeing a very angry population, and they don't go to fists anymore, they go right to guns," she said. "When we ask, 'Why did you shoot this guy?' it's, 'He bumped into me,' 'He looked at my girl the wrong way,' "said Police Commissioner Sylvester M. Johnson of Philadelphia. "It's not like they're riding around doing drive-by shootings. It's arguments - stupid arguments over stupid things." While arguments have always made up a large number of homicides, the police say the trigger point now comes faster. In robberies, Milwaukee's Chief Hegerty said, "Even after the person gives up, the guy with the gun shoots him anyway. We didn't have as much of that before."
What could be driving such a surge in violence? We can easily suspect that with a reported magnesium deficiency of almost 70 percent of the American population, we are witnessing the extreme end of the most severe deficiencies in the population. The two most basic requirements for the normal operation of our brain are a sufficient energy supply and an optimal presence of biochemicals involved in transmitting messages. Magnesium is crucial in both the production of energy and neurotransmitters, not to mention the integrity of the blood brain barrier. It is bedrock science that connects magnesium to neurological disorders.
Magnesium deficiency causes serotonin-deficiency with possible resultant aberrant behaviors, including depression suicide or irrational violence.
Magnesium of course is not the only nutrient whose deficiency is leading to broad problems of mind and emotion. Zinc is also an important mineral and is involved with psychiatric disorders. Over 90 metallo-enzymes require zinc and the functioning of the brain is dependent on adequate levels of zinc. Deficiency can cause amnesia, apathy, depression, irritability, lethargy, mental retardation and paranoia. As it is for magnesium and zinc it is for a host of basic nutrients though it is the mineral deficiencies that are the most important.
Numerous studies conducted in juvenile correctional institutions have reported that violence and serious antisocial behavior have been cut almost in half after implementing nutrient-dense diets.
But health officials and the pharmaceutical companies want to know nothing about using simple minerals to help depression or violence. Since the arrival of selective serotonin reuptake inhibitors antidepressants (SSRIs), and atypical antipsychotics on the market, countless studies have shown the so-called "new generation" of psychiatric drugs to be ineffective and dangerous. Worldwide, sales of anti-psychotics went from $263 million in 1986 to $8.6 billion in 2008 and antidepressant sales went from $240 million in 1986, to $11.2 billion in 2004, For these two classes of drugs combined, sales went from $500 million in 1986 to nearly $20 billion in 2004, a 40-fold increase, according to Robert Whitaker, best-selling author of Mad in America.
Despite a dramatic increase in treatment of psychiatric disorders during the past 10 years, there has been no decrease in the rate of suicidal thoughts and behavior among adults, according to a federal study primarily funded by the National Institute of Mental Health.
The Washington Post - June, 2005
Though it is a complex matrix of causes that cuts across physical, emotional, mental and spiritual levels of being - much of the blame for violence and depression can be laid on nutritional causes which are the easiest causes to correct. It is clear, for example, that magnesium deficiency or imbalance plays a crucial role in the symptoms of mood disorders. Observational and experimental studies have shown an association between magnesium and aggression,,,,, anxiety,,, ADHD,,,, bipolar disorder,, depression, ,,, and schizophrenia ,,,.
Patients who had made suicide attempts (by using either violent or nonviolent means) had significantly lower mean celebral spinal fluid magnesium level irrespective of the diagnosis.
The Department of Family Medicine, Pomeranian Medical Academy, states that dietetic factors can play a significant role in the origin of ADHD and that magnesium deficiency can result in disruptive behaviors. Even a mild deficiency of magnesium can cause sensitiveness to noise, nervousness, irritability, mental depression, confusion, twitching, trembling, apprehension, and insomnia.
Yet as Evelyn Pringle, investigative reporter, lets us know,
"Pharma will stop at nothing when it comes to making money off children. On April 25, 2005, the Ohio Columbus Dispatch reported an investigation of state Medicaid records that found 18 newborn to 3 years-old babies in Ohio had been prescribed antipsychotic drugs in July 2004. It is a horrible crime and terrible sadness what is being done to the children by pediatricians and psychiatrists who live by the increasingly popular creed to drug the kids with toxic substances."
When the body of a 19-year-old student, Traci Johnson, was found hanging from a shower rod in the laboratories of pharmaceuticals giant Eli Lilly, US officials were quick to announce that the death could not be linked to a new anti-depressant drug she was helping to test.
Magnesium ions have nutritional and pharmacologic actions that safely protects against the neurotoxicity of many agents up to and including stress from environmental noise and physical trauma. Magnesium deficiency, even when mild, increases susceptibility to various types of neurological and psychological stressors in both animals and healthy human subjects. "Mg deficiency increases susceptibility to the physiologic damage produced by stress. The adrenergic effects of psychological stress induce a shift of Mg from the intracellular to the extracellular space, increasing urinary excretion and eventually depleting body stores," reports Dr. Leo Galland.
Linus Pauling was one of the first who "highlighted the supremacy of nutrition in correcting abnormalities in the chemical environment of the brain." Nutrients like ascorbic acid, thiamin, niacinamide (vitamin B3), pyridoxine, vitamin B12, folic acid, magnesium, glutamic acid, and tryptophane were presented by Dr. Pauling as intimately linked to brain function and mental illness. In addition to strong bodies good nutrition helps us keep our mental health and emotional stability. With the proper diet containing the right nutrients in correct amounts, symptoms of mental illness can be rolled back and treated. Deficiencies in certain necessary nutrients lead to psychotic symptoms and depression while supplementation of other nutrients help attenuate and improve the symptoms of mental illness.
"In 1970 I read about Dr. Abram Hoffer's work and at that time was approached by a friend who had just been stopped from suiciding in a gas oven by her husband. She had her head in there and the gas on. She had also just begun a new drug, for bipolar (manic depression it was named then). She used to be admitted to the local Mental Hospital regularly every year at Spring Time. I began her on hi-dose B3, magnesium, Vitamin C and zinc. Today she is 90 and as bright as a button, very keen mind. In the subsequent 33 years she has only been in Mental wards once, and that was when she thought she was cured and didn't have to take her vitamin/mineral formula anymore. At that time we were also approached by a young man who had attempted suicide on the same drug. The same result we obtained for him. And this was only a small Western cattle and sheep town of 16,000 people. Since, the same results have been obtained in all who have come to me for depression, bipolar, schizophrenia."
-- Michael Sichel, D.O., N.D.
Chittaway Bay, New South Wales, Australia
In 2000, the National Institute of Health (NIH) listed depression as a sign of magnesium deficiency. NIH defined magnesium deficiency symptoms as having three categories:
- Early symptoms include (one or more) irritability, anxiety (including Obsessive Compulsion Disorder and Tourette syndrome), anorexia, fatigue, insomnia, and muscle twitching. Other symptoms include apathy, confusion, poor memory, poor attention and the reduced ability to learn.
- Moderate deficiency symptoms can consist of the above and possibly rapid heartbeat, irregular heartbeat and other cardiovascular changes (some being lethal).
- Severe deficiency symptoms can include one or more of the above symptoms and more severe symptoms including full body tingling, numbness, a sustained contraction of the muscles along with hallucinations and delirium, (including depression) and finally dementia (Alzheimer's Disease).
Mild magnesium deficiency appears to be common among patients with disorders considered functional or neurotic and appears to contribute to a symptom complex that includes asthenia, sleep disorders, irritability, hyperarousal, spasm of striated and smooth muscle and hyperventilation.
Normally joy, sadness and grief are parts of everyday life. While a short period of depression in our response to daily problems is normal, a long period of depression and sadness is abnormal. Most depressive episodes are triggered by a stressful personal event such as loss of a loved one or change of circumstances, and depression over a short period is a normal coping mechanism. Long-term stress-induced depression often results when magnesium falls to dangerously low levels in the body. One of the reasons it does this is because the stress itself depletes already meager cellular magnesium stores.
Repletion of deficiency typically reverses any increased stress sensitivity, and pharmacologic loading of magnesium salts orally, parenterally or transdermally induces resistance to neuropsychologic stressors. If the NIH knows this, why don't doctors use magnesium to treat depression and other mental (and physical) disorders asks George Eby, the developer of coldcure.com, who successfully treated himself with magnesium for depression.
George Eby's Testimonial
I remain truly amazed at the tremendous benefits of magnesium in treating and preventing depression. In particular, I see magnesium as an important research topic for survival considering its limited availability from our Western diets and due to its ability to inexpensively cure and prevent many expensive diseases, life threatening or not.
I know how bad depression can be, because I spent September of 1999 through April of 2000 in a clinical depression that worsened from the beginning. By Christmas the depression suddenly became much worse, nearly suicidal in intensity, and remained that way for four more months. Never did I think that things could go so wrong with my biochemistry that it would cause me to have suicidal thoughts and tendencies. How wrong I was. I had been taking Zoloft (an antidepressant) since 1987 which seemed to take care of my depression. I lived on Zoloft, but by September of 1999, it stopped working - and I knew that something was really wrong.
My depression was preceded by many years of major stress from over-work, anxiety, hypomania, fibromyalgia, infrequent panic attacks, anger, stress, poor diet, overwhelming emotional feelings, night time muscle spasms, paranoia, asthma, prickly sensations in hands, arms, chest and lips. I wanted to sleep all day and had trouble getting up in mornings. Occasionally my lips felt that they were going to vibrate or tingle off my face. About 10 years ago, I had a very painful bout with calcium oxalate kidney stones, a recognized sign of magnesium deficiency. A few weeks before I was hospitalized in January of 2000, I had very low energy, mental fogginess, depression with strange suicidal thoughts and I was under enormous stress.
Now, I can recognize these "mental" symptoms as symptoms of magnesium deficiency and/or calcium toxicity. I was put on nearly every antidepressant drug known and had severe side effects to all of them and felt sicker and sicker. None worked. I lost a lot of weight, and I was extremely constipated. I also had a cardiac arrhythmia.
On April 12, 2000, I looked like I was dying to several people important in my life. My psychiatrist agreed and took me off all antidepressant medications and put me on a tiny amount of lithium carbonate (150 mg twice a day). Shortly later, I picked up a 1975 copy of Nutrition Almanac, McGraw-Hill Book Company, New York, and happened to open it to the magnesium section. I was interested to find that magnesium was low in the serum of people who were suicidal and depressed. The article indicated that magnesium dietary supplements had been effective in treating depression. Also, a person with a magnesium deficiency is apt to be uncooperative, withdrawn, apathetic, and nervous, have tremors, essentially lots of neurological symptoms associated with depression.
Just a few months previous to the onset of my depression, I had been hospitalized for chest pain, cardiac dysrhysthmia and an inability to take in more than about 1/5 my normal breath. The hospital found no cardiac problems, and the internist gave me an IV drip of magnesium sulfate solution. A few hours later all of those symptoms vanished as rapidly as they had come. What I was beginning to see was that nearly all illnesses in my adult life were magnesium deficit related.
So finally I made the decision to start taking magnesium at a level 3 times the 400 mg/day RDA for magnesium, with 400 mg in the morning, 400 mg mid afternoon and 400 mg at bedtime. I used Carlson's chelated magnesium glycinate (200 mg magnesium elemental) product. Within a few days to a short week, I felt remarkably better, my depression lifted noticeably, but I was getting a bit of diarrhea.
Within a week to 10 days of starting magnesium, I felt close to being well. I looked so well, that my psychiatrist thought I looked better than he had ever seen me. As I improved, I lowered my dosage of magnesium to find the best dosage for me. I lowered it too much and symptoms rapidly came back. Eventually, I stabilized the dosage at four 200-mg elemental magnesium (as magnesium glycinate) tablets a day. My depression is completely, totally, absolutely gone. I am active and can function mentally, emotionally, and physically at my best again. My vision and bowels also returned to normal.
For all the talk about protecting children in America, too many of our little ones are threatened by psychiatrists and psychologists who have betrayed the young. Millions of children are now taking psychotropic drugs, which are causing catastrophic problems that are going unreported. For a tragic trip into the violent hell these drugs are causing please read Evelyn Pringle's FDA Forgot A Few ADHD Drug Related Deaths and Injuries at usa.mediamonitors.net.
After High School shootings
The medical and educational establishments are conducting a skyrocketing campaign to get kids and their parents to "just say yes" to brain-altering pharmaceuticals, with the drug of choice being Ritalin, even though some report that Ritalin is a drug that has a more potent effect on the brain than cocaine. By far, the overwhelming majority of psychotropic prescriptions for children are given for attention deficit disorder (ADD) or attention deficit hyperactivity disorder (ADHD). In some instances, taking medicine is a prerequisite for attending school, with refusal to comply considered grounds for dismissal, or worse, removal of the child from the home by the state.
On top of everything else the Children's Hospital of Philadelphia has reported that 19% of newly diagnosed Type 2 diabetic children also have neurological diseases. Many of these children are being treated with psychiatric medications Zyprexa, Risperdal, Geodon, Seroquel, Clozaril, and Abilify. All of these drugs carry black box warnings to alert MD's about the dangers of diabetes. All these drugs would in all liklihood push down magnesium serum levels.
Do not, and I scream, do not trust psychologists, psychiatrists and the current drug-pushing culture of education.
Dr. Julian Whitaker
There is an international explosion of legal child drugging as parents, educators and politicians in mass have been thoroughly duped into believing that only by continuous heavy drugging from a very early age can the "afflicted" child possibly make it through life's worst. Teen suicides have tripled since 1960 in the United States. Today suicide is the leading cause of death (after car accidents) for 15- to 24-year-olds. Since the early 1990's millions of children around the world have taken antidepressants that health authorities are just now branding as suicidal agents. This is the other side of the magnesium deficiency, the nightmare of these drugs which only compounds and worsens the loss of magnesium from the body.
The scene has been long in the making for the patterned onslaught of psychiatry on the young. Psychiatry has only in the last two decades unleashed its devastating attack on children using lucrative chemical weapons on our youth - addictive psychotropic drugs posing as medication. Psychiatrists have created a generation of drug addicts and to a great extent they are making the crisis in children today worse when they should be helping to make things better for them.
Child psychiatrists are one of the most dangerous enemies not only of children but also of adults. They must be abolished.
Dr. Thomas Szasz
Professor of Psychiatry
According to Dr. Sydney Walker, author of The Hyperactivity Hoax, "Thousands of children put on psychiatric drugs are simply smart. These students are bored to tears, and people who are bored fidget, wiggle, scratch, stretch, and (especially if they are boys) start looking for ways to get into trouble." What this chapter adds to that is the underlying complication these children face when their magnesium levels are too low and the devastation that rains down on them in the form of psychiatric medications.
If we look at the whole picture what do we see? Children are born under medical stress with unnatural procedures and drugs, they are then vaccinated, ie., bombarded with terrible chemicals, dosed out with antibiotics, eat terrible food, watch inordinate amounts of television, suffer through educational curriculums from the stone age, undergo exposure to thousands of chemical poisons in the environment and home, get more vaccines, suffer from malnutrition while stuffing their face to the point of obesity, only to have to suffer through being drugged by psychiatrists further for becoming the mess they have become.
Psychologists and psychiatrists should know better because of their training in mind and emotion so it is a terrible betrayal of humanity to see them turn into drug dealers. The pharmaceuticals that the drug companies produce for these mental health care workers are as dangerous as any of the drugs dealers on the streets sell. Magnesium should be substituted for these drugs not only because it is very effective in relieving neurological disorders but because it is vastly safer than any pharmaceutical.
Mark Sircus Ac., OMD
Director International Medical Veritas Association
www.skype.com ID: marksircus
IMPORTANT DISCLAIMER: Informational purposes only. Nothing in this paper is intended to be a substitute for professional medical advice.
Copyright 2006 International Medical Veritas Association. All rights reserved.
 Murck H. Magnesium and Affective Disorders. Nutr Neurosci., 2002;5:375-389: Murck showed many actions of magnesium ions supporting their possible therapeutic potential in affective disorders. Examinations of the sleep-electroencephalogram (EEG) and of endocrine system points to the involvement of the limbic-hypothalamus-pituitary-adrenocortical axis because magnesium affects all elements of this system. Magnesium has the property to suppress hippocampal kindling, to reduce the release of adrenocorticotrophic hormone (ACTH) and to affect adrenocortical sensitivity to ACTH. The role of magnesium in the central nervous system could be mediated via the N-methyl-D-aspartate-antagonistic, g-aminobutyric acid A-agonistic or the angiotensin II-antagonistic property of this ion. A direct impact of magnesium on the function of the transport protein p-glycoprotein at the level of the blood-brain barrier has also been demonstrated, possibly influencing the access of corticosteroids to the brain. Furthermore, magnesium dampens the calcium ion-protein kinase C related neurotransmission and stimulates the Na-K-ATPase. All these systems have been reported to be involved in the pathophysiology of depression. Murck et al. also demonstrated induced magnesium deficiency in mice to produce depression-like behavior which was beneficially influenced with antidepressants.
 Evelyn Pringle: www.lawyersandsettlements.com
 Izenwasser SE et al. Stimulant-like effects of magnesium on aggression in mice. Pharmacol Biochem Behav 25(6):1195-9, 1986.
 Henrotte JG. Type A behavior and magnesium metabolism. Magnesium 5:201-10, 1986.
 Bennett CPW, McEwen LM, McEwen HC, Rose EL. The Shipley Project: treating food allergy to prevent criminal behaviour in community settings. J Nutr Environ Med 8:77-83, 1998.
 Kirow GK, Birch NJ, Steadman P, Ramsey RG. Plasma magnesium levels in a population of psychiatric patients: correlation with symptoms. Neuropsychobiology 30(2-3):73-8, 1994.
 Kantak KM. Magnesium deficiency alters aggressive behavior and catecholamine function. Behav Neurosci 102(2):304-11, 1988
 Buist RA. Anxiety neurosis: The lactate connection. Int Clin Nutr Rev 5:1-4, 1985.
 Seelig MS, Berger AR, Spieholz N. Latent tetany and anxiety, marginal Mg deficit, and normocalcemia. Dis Nerv Syst 36:461-5, 1975.
 Durlach J, Durlach V, Bac P, et al. Magnesium and therapeutics. Magnes Res 7(3/4):313-28, 1994.
 Durlach J. Clinical aspects of chronic magnesium deficiency, in MS Seelig, Ed. Magnesium in Health and Disease. New York, Spectrum Publications, 1980.
 Kozielec T, Starobrat-Hermelin B. Assessment of magnesium levels in children with attention deficit hyperactivity disorder (ADHD). Magnes Res 10(2):143-8, 1997.
 Kozielec T, Starobrat-Hermelin B. Assessment of magnesium levels in children with attention deficit hyperactivity disorder (ADHD). Magnes Res 10(2):143-8, 1997.
 Starobrat-Hermelin B, Kozielec T. The effects of magnesium physiological supplementation on hyperactivity in children with attention deficit hyperactivity disorder (ADHD). Positive response to magnesium oral loading test. Magnes Res 10(2):149-56, 1997.
 George MS, Rosenstein D, Rubinow DR, et al. CSF magnesium in affective disorder: lack of correlation with clinical course of treatment. Psychiatry Res 51(2):139-46, 1994.
 Kirov GK, Birch NJ, Steadman P, Ramsey RG. Plasma magnesium levels in a population of psychiatric patients: correlations with symptoms. Neuropsychobiology 1994;30(2-3):73-8, 1994.
 Linder J et al. Calcium and magnesium concentrations in affective disorder: Difference between plasma and serum in relation to symptoms. Acta Psychiatr Scand 80:527-37, 1989
 Frazer A et al. Plasma and erythrocyte electrolytes in affective disorders. J Affect Disord 5(2):103-13, 1983.
 Bjorum N. Electrolytes in blood in endogenous depression. Acta Psychiatr Scand 48:59-68, 1972.
 Cade JFJA. A significant elevation of plasma magnesium levels in schizophrenia and depressive states. Med J Aust 1:195-6, 1964.
 Levine J, Rapoport A, Mashiah M, Dolev E. Serum and cerebrospinal levels of calcium and magnesium in acute versus remitted schizophrenic patients. Neuropsychobiology 33(4):169-72, 1996.
 Kanofsky JD et al. Is iatrogenic hypomagnesemia common in schizophrenia? Abstract. J Am Coll Nutr 10(5):537, 1991.
 Kirov GK, Tsachev KN. Magnesium, schizophrenia and manic-depressive disease. Neuropsychobiology 23(2):79-81, 1990.
 Chhatre SM et al. Serum magnesium levels in schizophrenia. Ind J Med Sci 39(11):259-61, 1985.
 Banki CM, Vojnik M, Papp Z, Balla KZ, Arato M. Cerebrospinal fluid magnesium and calcium related to amine metabolites, diagnosis, and suicide attempts. Biol Psychiatry. 1985 Feb;20(2):163-71.
 The effects of magnesium physiological supplementation on hyperactivity in children with ADHD. Mag Res 1997; 10(2):149-56.
 Eli Lilly's newest antidepressant, Cymbalta (Duloxetine) had 6 suicides in the clinical trials, before it ever reached the market, and in people with no previous history of depression. The last and most publicized was the death of a young college girl, who had entered the clinical trial for some extra money while she was in school. She had.no depression, was a good student, social and well adjusted, found hanging by a noose after a dosage change of this forecasted blockbuster.
Eli Lilly posted the results of 45 clinical trials on their website in cooperation with recommendations for more transparency for the public, but failed to list the 5 trials with the information about these suicidal acts. Lilly defended its drug, saying that 4,142 depressed patients had taken Cymbalta and the deaths represent a 0.097% suicide rate. Besides, it said, it is the underlying depression - not the drug - that causes sufferers to become suicidal. FDA defended Lilly's position. Later a higher than expected rate of suicide attempts was observed in the open-label extensions of controlled studies of Cymbalta for stress urinary incontinence (SUI) in adult women.
I have lost my appetite (I weigh around 110 lbs) and loss of taste, hearing, sensation and even judgement. I can barely drive or walk. I am a highly educated woman who has lead a national biotechnology company and now I can barely have a conversation that makes sense. I feel absolutely 100% confident that Cymbalta has caused these side effects. I have a bachelors in science with major studies in pharmacology and medical sciences. I previously had meeting with executives and lead conferences that people would learn from me. Now I can not even stand up straight without feeling dizzy, confused, and paranoid. I am currently having problems with spelling and grammer. This use to be a strong skill of mine. I have been known to edit papers and rewrite many documents and now it is difficult for me to write an email.
Cymbalta is not approved for the treatment of SUI. The FDA is evaluating additional data to determine the relationship, if any, between suicidality and Cymbalta use.
 West, Jean, "Children's drug is more potent than cocaine," The Observer, London, Sept. 9, 2001.